论文部分内容阅读
沙棘油在各种病理条件下显示出的极良好效果,使得药理学家很早以前就感兴趣。推测认为,这可能是沙棘油中存在着适应原活性。正是由于这一原因,所以才研究沙棘油对恶性肿瘤发展的影响。 在对品系BalB/C雄性小鼠艾氏腺癌(腺癌按0.2ml199号培养基中7. 5×10~6癌瘤细胞接种在腹膜内)的实验中,接种后经24h开始用沙棘油治疗。在7昼夜治疗期间,用探管分别灌胃0.5ml/kg,1.0ml/kg和5.0ml/kg沙棘油。实验结束时,按恶性细胞数量算出抑制肿瘤生长百分率。已查明沙棘油具中等抗肿瘤活性,其活性随着投药量的增加而提高。与对照组同一指数相比,实验组中服0.5ml/kg沙棘油动物的肿瘤细胞量减少了1. 3倍(抑制率为24％)服1.0ml/kg沙棘油动物的肿瘤细胞量减少了1. 5倍(抑制率为35％),服5.0ml/kg沙棘油动物的肿瘤细胞量减少了1.7倍(抑制率为41％)。上述研究结果认为,应在肿瘤实验中进一步研究沙棘油的抗癌作用。
The excellent effect of sea buckthorn oil under various pathological conditions has made pharmacologists interested in it long ago. It is speculated that this may be due to the presence of adaptogenic activity in seabuckthorn oil. It is for this reason that the effects of sea buckthorn oil on the development of malignant tumors were studied. In an experiment on Ehrlichian adenocarcinoma of adenocarcinoma BalB/C male mice (adenocarcinoma was inoculated intraperitoneally in 0.2 ml of No. 199 medium in 7.5×10~6 cancer cells in the peritoneum), sea buckthorn oil was used after 24 h of inoculation. treatment. During the treatment of day and night, 0.5ml/kg, 1.0ml/kg and 5.0ml/kg sea buckthorn oil were intragastrically administered with a probe. At the end of the experiment, the percent inhibition of tumor growth was calculated as the number of malignant cells. Seabuckthorn oil has been identified with moderate anti-tumor activity, and its activity increases with the increase in the dosage. Compared with the same index in the control group, the amount of tumor cells in 0.5 ml/kg sea buckthorn oil in the experimental group decreased by 1.3 times (inhibition rate was 24%). The amount of tumor cells in 1.0 ml/kg sea buckthorn oil was reduced. 1. 5 times (inhibition rate of 35%), the amount of tumor cells in animals treated with 5.0 ml/kg sea buckthorn oil was reduced by 1.7 times (inhibition rate was 41%). The above results suggest that the anti-cancer effect of sea buckthorn oil should be further studied in tumor experiments.