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目的检测H型高血压患者同型半胱氨酸(Hcy)水平及分析叶酸治疗的最佳剂量。方法选择2016年1月~10月就诊于河北省保定市老年病医院的H型高血压患者282例,其中男性138例,女性144例。依据服用叶酸剂量不同分为:A组(108例)、B组(120例)和C组(54例)。A组每天口服叶酸5mg,B组口服叶酸10 mg,C组口服叶酸15 mg。均连续服用30 d。干预前和干预后30 d采用酶联免疫吸附法测定Hcy。结果≥60岁H型高血压患者Hcy水平高于30~59岁患者[(26.47±8.91)μmol/L vs.(22.21±10.94)μmol/L],差异有统计学意义(P<0.05)。男性患者的Hcy水平为(26.45±11.9)μmol/L,女性为(22.17±7.78)μmol/L,男性明显高于女性,差异有统计学意义(P<0.05)。A组、B组和C组服用叶酸后Hcy水平均明显降低,差异有统计学意义(P均<0.05),但B组Hcy水平下降更明显。结论 H型高血压患者年龄增加,Hcy水平升高,男性患者Hcy水平高于女性患者;服用叶酸10 mg/d为治疗高Hcy症的最佳剂量。
Objective To detect the level of homocysteine (Hcy) in patients with Hypertension and to analyze the optimal dose of folic acid therapy. Methods A total of 282 hypertensive patients with Hypertension admitted to the Geriatric Hospital of Baoding from January to October 2016 were selected, 138 males and 144 females. According to taking different doses of folate divided into: A group (108 cases), B group (120 cases) and C group (54 cases). Group A daily oral folic acid 5mg, B group oral folic acid 10mg, C group oral folic acid 15mg. Take 30 consecutive days. Hcy was measured by enzyme-linked immunosorbent assay before and 30 days after intervention. Results The Hcy level in Hypertensive patients ≥60 years old was higher than that in patients aged 30 ~ 59 years [(26.47 ± 8.91) μmol / L vs (22.21 ± 10.94) μmol / L], the difference was statistically significant (P <0.05). The Hcy level in male patients was (26.45 ± 11.9) μmol / L and in female subjects was (22.17 ± 7.78) μmol / L, which was significantly higher in males than in females (P <0.05). The levels of Hcy in group A, group B and group C after treatment with folic acid were significantly lower than those in group C (all P <0.05), but the level of Hcy in group B was more obvious. Conclusions The age of Hypertension patients increases and the level of Hcy increases. The Hcy level in male patients is higher than that in female patients. Folic acid 10 mg / d is the best dose for treating Hypertension.