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目的探讨低剂量结合型雌激素（ＣＥ）和安宫黄体酮（ＭＰＡ）对更年期症状的治疗作用。方法３４例绝经后妇女随机分为２组，试验组１７例，隔日口服ＣＥ０．６２５ｍｇ与ＭＰＡ２ｍｇ交替应用；对照组１７例，口服结合型雌激素０．６２５ｍｇ／ｄ，每月连续服用２５ｄ，后１０ｄ加用ＭＰＡ４ｍｇ。２组均连续服用４周期。结果实验组１例退出，对照组２例退出。两组比较治疗效果无差异（Ｐ＞０．０５），治疗前后更年期症状均明显改善（Ｐ＜０．０１）。两组用药后无血压升高、乳腺增生及子宫内膜增生，试验组无阴道出血及乳房胀痛，对照组６例（４０％）有规则性阴道出血、４例（２７％）有乳房胀痛（Ｐ＜０．０１，Ｐ＜０．０５）。结论绝经后妇女低剂量激素替代治疗（ＨＲＴ）具有用量小、副作用少、有效、安全、经济等优点。
Objective To investigate the therapeutic effect of low dose conjugated estrogen (CE) and medroxyprogesterone acetate (MPA) on menopausal symptoms. Methods 34 cases of postmenopausal women were randomly divided into two groups, the experimental group of 17 cases, the other day oral CE0.625mg and MPA2mg alternating application; control group of 17 cases, oral conjugated estrogen 0.625mg / d, monthly continuous take 25d, after 10d plus MPA4mg. 2 groups were taking 4 cycles continuously. Results One patient in the experimental group quit and two patients in the control group quit. The two groups had no significant difference in the treatment effect (P> 0.05), and the symptoms of menopause were significantly improved before and after treatment (P <0.01). No hypertension, hyperplasia of mammary gland and endometrial hyperplasia occurred in both groups. No vaginal bleeding and breast tenderness occurred in the experimental group. Regular vaginal bleeding occurred in 6 cases (40%) in the control group and breast swelling in 4 cases (27%) Pain (P <0.01, P <0.05). Conclusion Postmenopausal women with low dose hormone replacement therapy (HRT) with a small amount of side effects, effective, safe, economical and other advantages.