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目的:观察辛伐他汀治疗慢性心力衰竭患者血清C反应蛋白(C reactive protein,CRP)水平的变化及心功能的影响。方法:选慢性心衰患者120例,随机分为治疗组,按慢性心衰治疗指南给予常规治疗,治疗组加用辛伐他汀10mg,qd。分别于治疗前、治疗后3,6,9,12个月测定CRP、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)及6min步行距离,观察再住院例数及死亡率。结果:治疗组CRP明显降低、LVEF及6min步行距离明显增加,死亡率明显降低(P<0.05)。结论:辛伐他汀可以降低慢性心衰患者血清CRP水平,干预左室重塑,改善左室收缩功能。上述作用与其抗炎效应有关。
Objective: To observe the changes of serum C-reactive protein (CRP) and the influence of cardiac function in patients with chronic heart failure treated with simvastatin. Methods: 120 chronic heart failure patients were randomly divided into treatment group, according to chronic heart failure treatment guidelines for conventional treatment, the treatment group with simvastatin 10mg, qd. CRP, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) and 6-minute walking distance were measured before treatment and 3, 6, 9 and 12 months after treatment respectively. Results: The treatment group CRP decreased significantly, LVEF and 6min walk distance increased significantly, the mortality was significantly lower (P <0.05). Conclusion: Simvastatin can reduce serum CRP levels in patients with chronic heart failure, interfere with left ventricular remodeling and improve left ventricular systolic function. The above effect is related to its anti-inflammatory effect.