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多发性硬化(MS)是由多种致病因素引起的以中枢神经系统脱髓鞘病变为特征的自身免疫性疾病,其发病涉及遗传因素、环境因素、病毒感染等。虽然其确切的发病机制尚未完全清楚,但是近年来各种治疗方法从不同程度上缓解了病情,改善了临床症状,尤其是传统免疫学治疗方法的不断改进、自体外周血干细胞移植技术的完善和胞浆型磷脂酶A2 抑制剂作用机制的阐述为攻克MS奠定了坚实的理论和应用基础。
Multiple sclerosis (MS) is an autoimmune disease characterized by a variety of causative factors characterized by demyelinating lesions of the central nervous system. Its pathogenesis involves genetic factors, environmental factors, viral infections and the like. Although its exact pathogenesis is not yet fully understood, in recent years, various treatments have alleviated the disease to varying degrees and improved clinical symptoms. In particular, the continuous improvement of traditional immunological methods and the improvement of autologous peripheral blood stem cell transplantation Cytoplasmic phospholipase A2 inhibitor mechanism of action to overcome MS has laid a solid theoretical and applied foundation.