论文部分内容阅读
用放射免疫及化学分析方法，探讨了腹腔注射大剂量雌二醇对大鼠血压、神经降压素及微量元素的影响。结果表明，１．腹腔注射大剂量雌二醇，大鼠血压明显升高（Ｐ＜０．０５）；２．在大鼠血压升高的同时，其下丘脑、甲状腺、肾上腺及血浆中神经降压素的含量亦明显升高（Ｐ＜０．０５～０．０１），而垂体中神经降压素含量明显降低（Ｐ＜０．０１）；３．大鼠血浆中钙、镁、铜离子含量明显升高（Ｐ＜０．０５），而铁、锌离子含量无明显改变（Ｐ＞０．０５）。提示大剂量雌二醇可诱发大鼠血压升高，神经降压素及钙、镁、铜离子在该过程中可能起一定的作用。
Using radioimmunoassay and chemical analysis, the effects of intraperitoneal injection of high-dose estradiol on blood pressure, neurotensin and trace elements in rats were investigated. The result shows that: 1. High-dose intraperitoneal injection of estradiol, blood pressure was significantly increased (P <0.05); 2. In the rat blood pressure at the same time, the hypothalamus, thyroid, adrenal and plasma neurotensin levels were significantly increased (P <0.05 ~ 0.01), while the pituitary neurotensin content was significantly Reduce (P <0.01); 3. The content of calcium, magnesium and copper in the plasma of rats were significantly increased (P <0.05), while the content of iron and zinc did not change significantly (P> 0.05). These results suggest that high-dose estradiol may induce an increase in blood pressure in rats. Neurotensin and calcium, magnesium and copper ions may play a role in this process.