采用ＥＬＩＳＡ法动态观察２２例细菌Ｌ型败血症患者血清铜、锌超氧化物歧化酶（Ｃｕ、Ｚｎ－ＳＯＤ）和Ｃ反应蛋白（ＣＲＰ）的含量变化。结果表明，败血症患者血清Ｃｕ、Ｚｎ－ＳＯＤ明显低于非感染组和健康组（Ｐ＜０．０１），而缓解期Ｌ型仍然存在，故仍显著低于败血症期（ｐ＜０．００１）；而同期血清ＣＲＰ未有明显变化（Ｐ＞０．０５）。提示，细菌Ｌ型败血症患者测定血清ＣＲＰ的同时检测Ｃｕ、Ｚｎ－ＳＯＤ含量有助于估计病情，指导治疗，判断预后。 The changes of serum copper, zinc superoxide dismutase (Cu, Zn-SOD) and C-reactive protein (CRP) in 22 patients with bacterial L-type sepsis were observed by ELISA. The results showed that serum levels of Cu and Zn-SOD in sepsis patients were significantly lower than those in non-infected patients and healthy patients (P <0.01), while those in remission still existed, which were still significantly lower than those in sepsis patients (p <0.001) ; While the same period of serum CRP did not change significantly (P> 0.05). Tip, bacterial L-type sepsis in patients with serum CRP determination of Cu, Zn-SOD levels help to assess the disease, guide the treatment, to determine the prognosis.