目的 :研究 90年代温州地区痢疾杆菌耐药性及菌群分布特点。方法 :对 1990年至 1999年来我院门诊及住院的腹泻病人进行粪便细菌培养及药敏试验。结果 :从 4136份标本中检出痢疾志贺氏菌共 5 84株 ,总检出率 14.12 % ,其中福氏菌 (B群 )占 98.76 %。药敏试验结果显示 ,痢疾杆菌 (B群 )对氯霉素、四环素、优力新等明显耐药 ,对庆大霉素、氟喹诺酮类等较敏感 ,对第三代头孢菌素、丁胺卡那、泰能皆敏感。结论 :90年代温州地区福氏菌为主要流行菌群 ,其耐药性有所增加 ,提示应合理用药 Objective: To study the characteristics of dysentery bacillus resistance and flora distribution in Wenzhou in the 1990s. Methods: Stool bacterial culture and drug sensitivity test were performed on diarrhea patients from 1990 to 1999 in our hospital. Results: A total of 5 84 strains of Shigella dysenteriae were detected from 4136 specimens, the total detection rate was 14.12%. Among them, 98.76% of them were group B (F). Drug susceptibility test results show that dysentery bacillus (B group) of chloramphenicol, tetracycline, Youlixin significantly resistant to gentamicin, fluoroquinolones and other more sensitive to the third generation cephalosporins, butylamine Kana, Thai are sensitive. Conclusion: In the 1990s, the genus Fusarium was the main epidemic group in Wenzhou, which increased its resistance, suggesting that rational use should be made