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为探讨肿瘤转移抑制基因 nm23-H_1在乳腺癌中的免疫组化表达特点及其与腋窝淋巴结转移和预后的关系,应用 S-P 法免疫组化技术对108例乳腺癌进行了研究.结果表明:①nm23-H_1在乳腺癌中阳性表达率为54.6%,各亚型之间阳性表达率无明显差异。阳性表达信号为癌细胞胞浆内呈现棕黄色颗粒。②108例中,5年无瘤生存率为58.3%,46例腋窝淋巴结转移者,5年无瘤生存率占71.7%,无瘤生存率与 nm23-H_1表达关系经卡方检验无统计学意义;③46例转移者,nm23-H_1阳性表达仅15例,占32.6%,而62例无转移者,阳性表达44例,占71.0%,两者差异有非常显著意义(P<0.01)。由此可见淋巴结转移与 nm23-H_1表达结果关系密切。
To explore the immunohistochemical features of tumor metastasis suppressor gene nm23-H_1 in breast cancer and its relationship with axillary lymph node metastasis and prognosis, 108 cases of breast cancer were studied by SP immunohistochemistry. The results showed that: 1 nm23 The positive expression rate of -H_1 in breast cancer was 54.6%, and there was no significant difference in the positive expression rate of each subtype. The positive expression signal showed brownish yellow particles in the cytoplasm of cancer cells. In 2108 cases, the 5-year disease-free survival rate was 58.3%. In 46 cases of axillary lymph node metastases, the 5-year disease-free survival rate accounted for 71.7%. The relationship between tumor-free survival rate and nm23-H1 expression was not statistically significant by chi-square test; Of the 346 metastatic cases, only 15 cases (32.6%) were positive for nm23-H1, while 62 cases had no metastasis and 44 cases were positive, accounting for 71.0%. There was a significant difference between the two groups (P<0.01). This shows that lymph node metastasis is closely related to the expression of nm23-H_1.