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目的 :探讨金艾康 (汉防己甲素片 )合用化学药物治疗肿瘤的临床增效作用。方法 :通过比较治疗组与对照组 (金艾康合并化学药物者为治疗组 ,单用化学药物者为对照组 ,每组各为 3 0例 )的总缓解率与毒副反应来评价金艾康对化疗药物的增效作用。结果 :治疗组与对照组的总缓解率分别为 80 %与 66.7% ,其中部分毒副反应如消化道反应与肢端麻木症状等治疗组明显低于对照组。结论 :金艾康具有对化学药物治疗肿瘤增效作用 ,其作用机理可能是逆转MDR ,并能降低化学药物引起的如消化道反应与肢端麻木症状等毒副作用
Objective: To investigate the clinical synergistic effect of Jin Ai-Kang (tetrandrine tablets) combined with chemical drugs in the treatment of tumors. METHODS: Jin Ai-Kang’s chemotherapeutic drugs were evaluated by comparing the total remission rate and toxic and side effects between the treatment group and the control group (the Jin Yikang combined chemotherapy drug was the treatment group, the single use of the chemical drug was the control group, each group was 30 cases). The synergies. Results: The total remission rates of the treatment group and the control group were 80% and 66.7% respectively. Some of the toxicities such as the digestive tract reaction and the numbness of the extremities were significantly lower than the control group. Conclusion: Jin Ai-Kang has the synergistic effect of chemotherapy on tumors. Its mechanism of action may be to reverse MDR and to reduce toxic side effects such as digestive tract reactions and acrosomatic symptoms caused by chemical drugs.