目的探讨黄藤素联合双八面体蒙脱石对小儿真菌性肠炎的疗效及安全性。方法采用随机对照试验的方法,将临床诊断为真菌性肠炎的120例患儿随机分为两组各60例,治疗组给予黄藤素片,每次0.05~0.30 g,每日3次口服或0.40~0.60 g,保留灌肠,加双八面体蒙脱石每次1.5~3.0 g,每日3或4次口服;对照组给予制霉菌素5~15万U.kg-1.d-1,每日3次口服,加表飞鸣每次0.15~0.30 g口服,每日3次,均连用3~5 d。结果治疗组总有效率(96.55%)明显高于对照组(70.37%)(P<0.01),且治疗组治愈时间明显缩短(P<0.01)。治疗组不良反应发生率(1.72%)明显低于对照组(37.04%)(P<0.01)。结论黄藤素联合双八面体蒙脱石治疗小儿真菌肠炎疗效显著,可缩短疗程,安全性好,值得临床推广。 Objective To investigate the efficacy and safety of combination of saponin and double octahedral montmorillonite on infantile fungal enteritis. Methods 120 cases of clinical diagnosis of fungal enteritis were randomly divided into two groups of 60 cases. The treatment group was given palmatine tablets (0.05-0.30 g each time), three times a day orally or 0.40 ~ 0.60 g, retention enema, double dioctahedral smectite each 1.5 ~ 3.0 g, 3 or 4 times a day orally; the control group was given nystatin 50000 U.kg-1.d-1, 3 times a day orally, add on behalf of Fei Ming 0.15 ~ 0.30 g orally, 3 times a day, were used even 3 ~ 5 d. Results The total effective rate (96.55%) in the treatment group was significantly higher than that in the control group (70.37%) (P <0.01), and the cure time in the treatment group was significantly shorter (P <0.01). The incidence of adverse reactions in the treatment group (1.72%) was significantly lower than that in the control group (37.04%) (P <0.01). Conclusion The combination of saponin and double octahedral montmorillonite is effective in treating infantile fungal enteritis. It can shorten the course of treatment and has good safety. It is worthy of clinical promotion.