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阿托品或莨菪碱有机酯是右旋莨菪碱和左旋莨菪碱的消旋混合物,其中只左旋异构体有药理活性。阿托品与东莨菪碱都是抗副交感的或通过竞争性拮抗受节后胆碱能神经支配组织的乙酰胆碱作用(象平滑肌、心肌组织、外分泌腺和中枢神经系统)而起毒蕈碱阻滞效应。胃长宁是人工合成的季铵化合物,由于它的正电荷而不能穿透血脑屏障和胎盘,所以很少引起中枢神经系或新生儿中毒。
Atropine or scopolamine organic esters are racemic mixtures of dextromethorphan and levamisodamine, of which only the levorotatory isomer has pharmacological activity. Both atropine and scopolamine are antagonistic to parasympathetic or muscarinic blockade by competitive antagonism of the acetylcholine effects of the post-sympathetic tissues of postganglionic cholinergic arteries such as smooth muscle, cardiac muscle tissue, exocrine glands and the central nervous system. Stomach Changning is a synthetic quaternary ammonium compound, due to its positive charge can not penetrate the blood-brain barrier and the placenta, it rarely causes central nervous system or neonatal poisoning.