目前肝癌是世界上最常见的恶性肿瘤之一,有着较高的发病率和病死率。随着超声造影技术与分子生物学的不断发展,超声微泡造影剂携带基因治疗肿瘤是当前的研究的热点,为肿瘤治疗带来了新的希望。超声靶向击破技术为肝癌基因治疗方面提供了一种强有效的非病毒途径,具有广泛的应用潜力。现将超声微泡联合基因靶向治疗肝癌的研究现状作一综述。 At present, liver cancer is one of the most common malignant tumors in the world, with a high morbidity and mortality. With the continuous development of contrast-enhanced ultrasound and molecular biology, ultrasound microbubble contrast agents to carry gene therapy for cancer is the current research hotspot, bringing new hope for cancer treatment. Ultrasound targeted rupture technology provides a powerful non-viral pathway for gene therapy of hepatocellular carcinoma, which has a wide range of potential applications. Now ultrasound microbubbles gene therapy for the treatment of liver cancer are reviewed.