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当今恶性脑瘤的治疗仍以手术为主,放疗化疗为辅,但效果均不满意。几乎所有的恶性脑瘤在手术后难免复发,此时,化疗往往成为治疗的主要手段。同时,欲根治脑瘤或希望获得较长时间的缓解,化疗也是综合治疗中的重要环节。但血脑屏障(BBB)的存在使大多数抗癌药很难进入脑内或通透较少,这不仅脑瘤的化疗无效,而且容易引起肿瘤细胞的抗药性。因此,脑瘤化疗中的血脑屏障是有待克服的困难之一。近年来,国外学者采用颈动脉注射高渗液的方法,改变BBB,使之达到一种可
The current treatment of malignant brain tumors is still based on surgery, supplemented by radiotherapy and chemotherapy, but the effect is not satisfactory. Almost all malignant brain tumors inevitably recur after surgery. At this time, chemotherapy is often the main method of treatment. At the same time, chemotherapy is also an important part of comprehensive treatment in order to cure brain tumors or hope to obtain a longer period of remission. However, the presence of the blood-brain barrier (BBB) makes it difficult for most anticancer drugs to enter the brain or have low permeability. This not only has no effect on the chemotherapy of brain tumors, but also easily causes the resistance of tumor cells. Therefore, the blood-brain barrier in brain tumor chemotherapy is one of the difficulties to be overcome. In recent years, foreign scholars have used the method of injecting hypertonic fluid into the carotid artery to change the BBB so that it can reach a