目的探讨双硫仑样反应及其救治方法,以及做好对双硫仑样反应知识的宣传教育,给予患者充分的护理干预,从而减少双硫仑样反应的发生率。方法对我科自2005年5月至2010年11月诊断为双硫仑样反应的72例患者的诊疗情况进行回顾性分析。结果①患者以男、青壮年为主;②用药以头孢类抗生素为主,其他类药物少见;③患者发病时的饮酒量均少于平日最大饮酒量;④发病均在用药期间及用药后一周内;⑤患者起病迅速,来势凶猛,但预后较好,本组病例均康复出院。结论药源性双硫仑样反应的发病率逐年增高,其临床表现严重,必须引起医护人员的高度重视,同时医护人员必须对患者及其家属进行健康教育。 Objective To explore the disulfiram-like response and its treatment methods, as well as publicize and disseminate the knowledge of disulfiram-like reaction, and give patients adequate nursing intervention to reduce the incidence of disulfiram-like reaction. Methods The clinical data of 72 patients diagnosed as disulfiram-like reaction from May 2005 to November 2010 in our department were analyzed retrospectively. Results ① The patients were mainly male and young adults; ② The drugs were mainly cephalosporins and the other drugs were rare; ③ The drinking amount of the patients at the time of onset was less than the maximum daily drinking amount; ④ The incidence was both during the medication and one week after the medication ; ⑤ patients with rapid onset, ferocious, but the prognosis is better, this group of patients were discharged. Conclusions The incidence of drug-induced disulfiram-like reaction has been increasing year by year. The clinical manifestations of the drug-induced disulfiram-like reaction have been increasing year by year. Medical staffs must attach great importance to this situation. At the same time, health care workers must provide health education to patients and their families.