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充血性心力衰竭(CHF)是一种常见临床综合征。本文就其某些基础理论和治疗学研究进展作一综述。 CHF按病理生理分为三类:(1)原发性心肌收缩力减弱。由冠心病、扩张性心肌病、弥漫性心肌炎等引起。(2)继发性心肌收缩力减弱。由可致心脏负荷过重的各种疾病引起。(3)心室舒张功能(顺应性)减退,前负荷不足。由舒张期充盈受限引起,如单纯肥厚的心室。一、基础理论研究方面: (一) CHF生物化学: 早年认为衰竭心肌贮存的NE(去甲肾上腺素)耗尽。近来发现几乎所有CHF患者血浆NE
Congestive heart failure (CHF) is a common clinical syndrome. This article reviews some of its basic theories and advances in therapeutic research. CHF by pathophysiology is divided into three categories: (1) primary myocardial contractility decreased. Caused by coronary heart disease, dilated cardiomyopathy, diffuse myocarditis and so on. (2) Secondary myocardial contractility weakened. Caused by heart overload caused by a variety of diseases. (3) ventricular diastolic function (compliance) decreased, before the load is insufficient. Limited by the diastolic filling caused, such as simple hypertrophy of the ventricle. First, the basic theory of research: (A) CHF biochemistry: Early that the depleted myocardium stored NE (norepinephrine) depleted. Recently, almost all patients with CHF found plasma NE