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目的探讨T2DM患者臀围与MS危险因素的相关性,为MS病因研究及其防治提供依据。方法选取2013~2015年糖尿病专科门诊确诊的T2DM患者8771例,采用Logistic回归分析不同臀围水平对MS的患病风险。结果多因素非条件Logistic回归结果表明,女性、C-RP≥2.80 mg/L、WC≥94 cm、臀围≥101 cm和BMI≥28 kg/m~2[95%CI分别为1.13(1.03~1.23)、2.71(2.27~3.24)、2.36(2.24~2.47)、10.27(8.89~11.86)、25.27(20.20~31.61),P<0.01]为T2DM患者发生MS的独立危险因素。将T2DM患者按不同MS组分行单因素无序多分类Logistic回归分析,结果显示,与臀围<91 cm比较,91 cm~、96 cm~和≥101 cm在T2DM伴1种MS组分与仅有T2DM组分比较的OR(95%CI)分别为1.12(0.94~1.33)、1.47(1.20~1.81)和2.01(1.46~2.76),且存在剂量反应关系(χ_(趋势)~2=5.13,P<0.01);T2DM伴2种或以上MS组分与仅有T2DM组分比较的OR(95%CI)分别为1.07(0.88~1.31)、1.51(1.20~1.90)和4.01(2.89~5.56),且存在剂量反应关系(χ_(趋势)~2=8.79,P<0.01)。结论大臀围是T2DM患者发生MS的独立危险因素。
Objective To investigate the correlation between hip circumference and MS risk factors in patients with T2DM and to provide basis for the study of the etiology and prevention of MS. Methods Totally 8771 T2DM patients diagnosed in Diabetes Outpatient Department from 2013 to 2015 were selected. Logistic regression was used to analyze the prevalence of MS at different hip levels. Results The results of multivariate non-conditional logistic regression showed that the C-RP≥2.80 mg / L, WC≥94 cm, hip≥101 cm and BMI≥28 kg / m ~ 2 [95% CI 1.13 (1.03 ~ 1.23), 2.71 (2.27 ~ 3.24), 2.36 (2.24 ~ 2.47), 10.27 (8.89 ~ 11.86), 25.27 (20.20 ~ 31.61), P <0.01] were independent risk factors for MS in T2DM. Logistic regression analysis of single-factor disorganized multinomial T2DM patients with different MS group showed that compared with hip <91 cm, 91 cm ~, 96 cm ~ and ≥101 cm in T2DM with only one MS and only The OR (95% CI) of T2DM components were 1.12 (0.94-1.33), 1.47 (1.20-1.81) and 2.01 (1.46-2.76), respectively, and there was dose response relationship (χ_ (trend) P <0.01). The OR (95% CI) of T2DM with two or more MS components and only T2DM components were 1.07 (0.88-1.31), 1.51 (1.20-1.90) and 4.01 (2.89-5.56) , And there was a dose-response relationship (χ_ (trend) ~ 2 = 8.79, P <0.01). Conclusion The large hip is an independent risk factor for MS in T2DM patients.