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目的探讨稽留流产患者外周血中血管粘附分子-1(VCAM-1)、干扰素-α(IFN-α)、内皮抑素(ES)的表达水平及其临床意义。方法采用酶联免疫吸附测定法分别测定45例稽留流产患者(流产组)和45例正常早孕孕妇(对照组)外周血中VCAM-1、IFN-α及ES的表达水平。结果流产组患者外周血中VCAM-1、IFN-α及ES水平分别为(296.7±67.4)μg/l、(58.2±13.6)pg/ml及(61.3±19.8)ng/ml,对照组分别为(485.6±96.1)μg/l、(18.4±6.2)pg/ml及(22.4±6.8)ng/ml,两组比较差异有统计学意义(P<0.05)。结论稽留流产患者外周血中的VCAM-1低水平表达,IFN-α及ES高水平表达可能是其重要发病机制之一。
Objective To investigate the expression of vascular cell adhesion molecule-1 (VCAM-1), interferon-α (IFN-α) and endostatin (ES) in patients with missed abortion and its clinical significance. Methods The expression of VCAM-1, IFN-α and ES in 45 cases of missed abortion (abortion group) and 45 cases of normal early pregnant women (control group) were determined by enzyme-linked immunosorbent assay. Results The levels of VCAM-1, IFN-α and ES in the peripheral blood of the abortion group were (296.7 ± 67.4) μg / l, (58.2 ± 13.6) pg / ml and (61.3 ± 19.8) ng / (485.6 ± 96.1) μg / l, (18.4 ± 6.2) pg / ml and (22.4 ± 6.8) ng / ml, respectively. There was significant difference between the two groups (P <0.05). Conclusions The low expression of VCAM-1 in the peripheral blood of patients with missed abortion and the high expression of IFN-α and ES may be one of the important pathogenesis.