系膜IgA沉积的肾小球肾炎,又称Berger氏病(下称GNDM IgA),原属常见肾脏病之一。在法国占成人肾小球肾炎20～25%,迄今未见痊愈者。但由于进展非常缓慢,故多不至发展到肾功能衰竭。使人惊奇的是现在发现本病竟占需进行肾移植的肾衰竭终末期患者的10%。 1970～1977年作者在Necker医院共作240例次肾脏移植,将宿主肾脏片用超微切刀切成3μm薄片,以供免疫荧光技术研究,发现24例为GNDMIgA。男18例,女6例(比传统统计为高)。患者病程长短悬殊(1～35年),10年以上者6例。此系开始症状轻重不一,而致确诊迟早大不相同之故。24例中首见症状,以肉眼血尿开始者10例,尿常规异常9例,高血压3例,急性肾炎综合征或肾功能衰竭者各1例。本文中GNDM IgA的发病率较生前活检发现者为高;因为本病常以镜下血尿或轻度蛋白尿开始,以致 Mesangial IgA deposition of glomerulonephritis, also known as Berger’s disease (hereinafter referred to as GNDM IgA), is one of the common kidney disease. In France accounted for 20 to 25% of adult glomerulonephritis, so far no cure. However, due to the very slow progress, it is often not developed to renal failure. Surprisingly, it has now been found that this disease accounts for 10% of end-stage renal failure patients who need renal transplantation. From 1970 to 1977, a total of 240 kidneys were transplanted in Necker Hospital. The kidneys of the kidney were cut into 3μm slices with a microdissector for immunofluorescence. 24 cases were found to be GNDMIgA. 18 males and 6 females (higher than the traditional statistics). Length of disease in patients with disparity (1 to 35 years), 10 years in more than 6 cases. This is the beginning of the symptoms of varying severity, which led to the diagnosis of very different sooner or later therefore. In 24 cases, the first symptom was seen in 10 cases of gross hematuria, 9 cases of abnormal urine, 3 cases of hypertension, 1 case of acute nephritic syndrome or 1 case of renal failure. In this paper, the incidence of GNDM IgA is higher than those found in prenatal biopsies; because this disease often starts with microscopic hematuria or mild proteinuria,