论文部分内容阅读
目的观察加巴喷丁联合阿米替林治疗神经病理性疼痛的临床疗效。方法将90例神经病理性疼痛患者分为观察组48例、对照组42例,分别给予加巴喷丁联合阿米替林治疗4周和单纯应用加巴喷丁治疗4周。采用VAS评分方法评估疗效,观察不良反应发生率。结果观察组有效率显著高于对照组、不良反应率显著低于对照组,差异有统计学意义(P<0.05)。与对照组比较,观察组治疗后VAS评分明显下降,差异有统计学意义(P<0.05)。结论加巴喷丁联合阿米替林治疗神经病理性疼痛安全有效。
Objective To observe the clinical efficacy of gabapentin combined with amitriptyline in the treatment of neuropathic pain. Methods Ninety patients with neuropathic pain were divided into observation group (n = 48) and control group (n = 42). The patients were treated with gabapentin plus amitriptyline for 4 weeks and gabapentin alone for 4 weeks respectively. The VAS score was used to evaluate the curative effect and the incidence of adverse reactions was observed. Results The effective rate of the observation group was significantly higher than that of the control group, the adverse reaction rate was significantly lower than the control group, the difference was statistically significant (P <0.05). Compared with the control group, the VAS score of observation group decreased significantly after treatment, the difference was statistically significant (P <0.05). Conclusion Gabapentin combined with amitriptyline in the treatment of neuropathic pain is safe and effective.