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在引起高Ca血症的疾病中,人们关注之点颇多,包括原发性甲状旁腺功能亢进症、无症状性家族性低尿Ca性高Ca血症及最近深受重视的恶性肿瘤伴发的高Ca血症。现仅就后者作一概述。恶性肿瘤并发高Ca血症的发病率很高,且有很多病例为急剧进展型,因此已成为恶性肿瘤的一种严重并发症。并发高钙血症的原因是肿瘤细胞分泌细胞因子如PTHrP、IL-1等骨吸收刺激因子(BRSF),刺激成骨细胞,后者又分泌破骨细胞刺激因子,从而促进破骨细胞的溶骨作用,引起高Ca血症。BRSF包括很
Among the diseases that cause hypercalcaemia, there are many points of concern, including primary hyperparathyroidism, asymptomatic familial low urinary Ca-type hypercalcaemia and the recently-noted malignancy Fat hypercalcemia. The latter is only an overview. Malignant tumors with high incidence of hypercalcemia, and many cases of rapid progress, it has become a serious complication of malignant tumors. The cause of complicated hypercalcaemia is the secretion of cytokines such as PTHrP, IL-1 and other bone resorption stimulating factors (BRSFs) by tumor cells to stimulate osteoblasts, which in turn secrete osteoclast stimulating factors and thus promote osteoclastogenesis Bone function, causing hypercalcemia. BRSF includes very much