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目的:探讨p16蛋白表达与食管癌发生发展的关系.方法:应用免疫组织化学方法检测了79例食管癌(原位癌30例,浸润性鳞状细胞癌19例,腺癌30例)及其116例增生性病变(单纯增生30例,不典型增生轻31例、中31例、重24例)和28例正常食管黏膜上皮组织中p16蛋白表达情况.结果:p16蛋白表达的阳性率分别为侵袭性鳞状细胞癌21.1%(4/19)、原位癌50%(15/30)、重度不典型增生83.3%(20/24)、中度不典型增生64.5%(20/31)、轻度不典型增生67.7%(20/31)、单纯增生80%(24/30)、正常组织60.7%(17/28).结论:p16蛋白表达的缺失可能与食管癌的发生发展有关.
Objective: To investigate the relationship between the expression of p16 and the development of esophageal carcinoma.Methods: 79 cases of esophageal cancer (30 cases of carcinoma in situ, 19 cases of invasive squamous cell carcinoma and 30 cases of adenocarcinoma) were detected by immunohistochemistry 116 cases of hyperplastic lesions (simple hyperplasia in 30 cases, atypical hyperplasia in 31 cases, 31 cases, 24 cases of weight) and 28 cases of normal esophageal mucosa epithelial tissue p16 protein expression.Results: The positive rates of p16 protein expression were Invasive squamous cell carcinoma was 21.1% (4/19), carcinoma in situ was 50% (15/30), severe dysplasia was 83.3% (20/24), moderate dysplasia was 64.5% (20/31) Mild atypical hyperplasia 67.7% (20/31), simple hyperplasia 80% (24/30), normal tissue 60.7% (17/28) .Conclusion: The lack of p16 protein expression may be related to the occurrence and development of esophageal cancer.