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[目的]了解菏泽市手足口病的病原学特征,为手足口病的综合防治提供科学依据。[方法]收集2010~2011年菏泽市手足口病临床诊断病例的相关标本312份,采用实时荧光RT-PCR方法对标本进行肠道病毒核酸检测和型别鉴定。[结果]合计检测临床标本312份,阳性标本305份,总检出率为97.76%,其中EV71型占76.60%,CoxA16占11.54%。总肠道病毒阳性检出率,2010年为97.16%,2011年为98.25%(P<0.01);男性为98.62%,女性为95.79%(P>0.05);305份阳性标本中,1~3岁占74.75%,3~5月发病占90.82%。[结论]菏泽市手足口病的病原体主要是EV71和CoxA16,同时呈现多样化和复杂化的特点。
[Objective] To understand the etiological characteristics of hand-foot-mouth disease in Heze City and provide a scientific basis for the comprehensive prevention and treatment of hand-foot-mouth disease. [Method] A total of 312 samples of clinically diagnosed HFMD in Heze City from 2010 to 2011 were collected. Real-time fluorescence RT-PCR was used to detect the enteric virus nucleic acid and type identification. [Results] A total of 312 clinical specimens and 305 positive specimens were detected, the total detection rate was 97.76%, of which 76.60% were EV71 type and 11.54% were CoxA16. The positive rate of total enterovirus was 97.16% in 2010 and 98.25% in 2011 (P <0.01), 98.62% in males and 95.79% in females (P> 0.05). Among 305 positive samples, 1 to 3 Aged 74.75%, 3 to May disease accounted for 90.82%. [Conclusion] The pathogens of HFMD in Heze city are mainly EV71 and CoxA16, showing diversified and complicated characteristics at the same time.