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目的:探讨乙型肝炎肝组织Fas抗原表达与细胞凋亡和肝细胞损伤关系.方法:用免疫组织化学技术,对109例乙型肝炎肝组织Fas抗原进行了检测.结果:Fas抗原总检出率76.16%,急性重症肝炎(AFH),慢性迁延型肝炎(CPH),慢性活动型肝炎(CAH),活动性肝硬化(AC)Fas抗原检出率分别为90.9%,43.48%,78.12%,85.71%.急性重症肝炎Fas抗原阳性细胞分布于大片坏死区域中残留肝细胞内,慢性肝炎和活动性肝硬化Fas抗原阳性细胞分布在碎屑状坏死灶周围或假小叶周边肝细胞.Fas抗原阳性率经统计学处理,CPH组与AFH,CAH及AC组有显著性差异.结论:Fas抗原在病毒性肝炎时有介导细胞凋亡的作用,其表达与肝细胞损伤程度密切相关.
Objective: To investigate the relationship between Fas antigen expression and hepatocellular injury in hepatitis B liver tissue.Methods: Immunohistochemical technique was used to detect Fas antigen in 109 hepatitis B liver tissue.Results: The positive rate of Fas antigen in acute severe hepatitis (AFH), chronic persistent hepatitis (CPH), chronic active hepatitis (CAH) and active liver cirrhosis (AC) Fas antigen was 90.9%, 43.48%, 78.12% 85.71% .Acute severe hepatitis Fas antigen positive cells distributed in large areas of necrosis in the residual liver cells, chronic hepatitis and active cirrhosis of Fas antigen-positive cells distributed in the debris around the necrotic foci or peripheral lobules hepatocytes.Fas antigen positive Statistical analysis showed that there was significant difference between CPH group and AFH, CAH and AC group.Conclusion: Fas antigen can induce apoptosis in viral hepatitis and its expression is closely related to the degree of hepatocyte injury.