目的　观察逍遥丸与尼尔雌醇治疗围绝经期综合征的疗效与不良反应。方法　选择 4 2 5例围绝经期综合征病人 ,随机分为治疗组 2 2 2例与对照组 2 30例进行比较。结果　逍遥丸治疗组疗效明显 ,总有效率为 90 99% ,不良反应极小 ,差异均有显著意义 (P <0 0 5 )。结论　逍遥丸治疗围绝经期综合征疗效好 ,不良反应少。 Objective To observe the efficacy and adverse reactions of Xiaoyao Pill and nylestriol in the treatment of perimenopausal syndrome. Methods A total of 425 patients with perimenopausal syndrome were selected and randomly divided into treatment group (n = 232) and control group (n = 230). The results Xiaoyao pill treatment group was significantly effective, the total effective rate was 90 99%, with minimal adverse reactions, the difference was significant (P <0 05). Conclusion Xiaoyao Pill has a good curative effect on perimenopausal syndrome with few adverse reactions.