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目的:观察肝豆灵联合二巯丙磺酸钠治疗对痰瘀互结型肝豆状核变性患者血清丙二醇(MDA),超氧化物歧化酶(SOD)的影响,并探讨其作用机制。方法:选取安徽中医药大学第一附属医院脑病科确诊为肝豆状核变性的住院患者120例,随机分为对照组和治疗组,各60例,其中对照组使用二巯丙磺酸钠常规治疗,治疗组在常规治疗的基础上加用肝豆灵片,治疗4个疗程。在治疗前后分别进行血清MDA,SOD,24 h尿铜、神经功能评分等相关指标评估。结果:与治疗前比较,两组治疗后血清MDA含量均减低,SOD活性均增加(P<0.05),治疗组优于对照组(P<0.01);两组神经功能评分均下降(P<0.05),治疗组疗效优于对照组(P<0.01);两组治疗后24 h尿铜均有明显改善,其中治疗组改变显著(P<0.01),治疗组驱铜效果优于对照组(P<0.05);两组肝功能指标均有降低(P<0.05),治疗组显著优于对照组(P<0.01)。两组铜蓝蛋白与铜氧化酶治疗前后变化不大。根据两组不良反应分析,发现治疗组副作用小。结论:中西医结合治疗能明显降低肝豆状核变性患者中血清MDA含量,增加SOD活性,可以加强驱铜效果,改善临床症状,在一定程度上可以延缓病情进展,减轻患者痛苦。且不良反应较少,安全性高,在临床上得到广泛运用。
Objective: To observe the effect of Goupouling combined with sodium dimercaptopropane sulfonate on the serum levels of propylene glycol (MDA) and superoxide dismutase (SOD) in patients with hepatolenticular degeneration of phlegm and blood stasis and to explore its mechanism. Methods: A total of 120 hospitalized patients with hepatolenticular degeneration were enrolled in the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine. They were randomly divided into control group and treatment group, with 60 cases each. The control group was given sodium dimercaptopropane sulfonate Treatment, treatment group on the basis of conventional treatment with Gudou Ling tablets, the treatment of 4 courses. Before and after treatment were serum MDA, SOD, 24 h urinary copper, neurological score and other related indicators of assessment. Results: Compared with those before treatment, serum MDA content decreased and SOD activity increased (P <0.05), and the treatment group was better than the control group (P <0.01); The neurological function scores of both groups were decreased (P <0.05 ) In the treatment group was better than that in the control group (P <0.01). Urinary copper in 24 hours after treatment was significantly improved in both groups, of which the treatment group changed significantly (P <0.01) <0.05). The indexes of liver function in both groups were decreased (P <0.05), and the treatment group was significantly better than the control group (P <0.01). Two groups of ceruloplasmin and copper oxidase changes before and after little change. According to two groups of adverse reaction analysis, the treatment group found that side effects. Conclusion: The combination of TCM and WM can significantly reduce the content of serum MDA and increase the activity of SOD in patients with hepatolenticular degeneration, which can enhance the effect of removing copper and improve the clinical symptoms. It can delay the progression of the disease and alleviate the suffering of patients. And less adverse reactions, high safety, widely used in clinical practice.