大量研究显示瘦素在脂肪肝的形成中起重要作用。瘦素缺乏或作用障碍不仅使下丘脑分泌的神经肽Y水平升高,导致高胰岛素血症,机体内脂肪增多;而且瘦素抵抗可通过上调固醇调节元件结合蛋白-1的表达引起肝脏脂肪化的发生;同时高瘦素血症也可引起胰岛素抵抗,改变肝细胞内胰岛素的信号转导途径使肝细胞内脂肪酸增加。另外,瘦素通过放大选择性炎性介质反应使肝脏脂肪化。 Numerous studies have shown that leptin plays an important role in the formation of fatty liver. Leptin deficiency or dysfunction not only increases the level of neuropeptide Y secreted by the hypothalamus, leading to hyperinsulinemia, increased body fat; and leptin resistance can cause liver fat by up-regulating the expression of sterol regulatory element binding protein-1 The occurrence of hyperlipidemia can also cause insulin resistance, and change the signal transduction pathway of insulin in hepatocytes to increase the fatty acids in liver cells. In addition, leptin lifts the liver by amplifying selective inflammatory mediators.