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本文对小鼠全身大剂量照射加骨髓移植进行了研究。GB_(57)×BALB/C→F1小鼠接受700cGy全身照射(TBI),剂量率56cGy/分。第一组不作骨髓移植(BMT)时,存活期7～23天,均数13天。经病理证实,均死于骨髓衰竭。同时亦发现对肝、脾等亦有损害。第二组照射后,接受BALB/C同种异基因骨髓移植,但不加服环胞霉素A(CSA)时,在移植后9～49天,均值23天死于严重的移植物抗宿主反应(GVHD)。与上组比较,P<
In this study, mice were irradiated with whole body irradiation plus bone marrow transplantation. GB_(57)×BALB/C→F1 mice received 700 cGy total body irradiation (TBI) at a dose rate of 56 cGy/min. In the first group without bone marrow transplantation (BMT), the survival period was 7-23 days with an average of 13 days. Pathologically confirmed, all died of bone marrow failure. At the same time, it also found damage to the liver and spleen. After the second group of irradiation, they received BALB/C allogeneic bone marrow transplantation, but when they were not treated with cyclosporin A (CSA), they died from severe graft-versus-host disease on average 23 days after transplantation from 9 to 49 days. Reaction (GVHD). Compared with the previous group, P<