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口服类固醇避孕药(OCS)仍是目前最常用而可靠的避孕方法。虽然人们对OCS的副作用有着广泛的了解,但对该类药物与其他药物的相互作用却缺乏重视。早在1971年就有关于在应用抗生素而同时服用OCS者避孕失败的报道,随后又有关于青霉素、氨苄青霉素、羟氨苄青霉素、头孢氨苄、四环素、磺胺二甲异噁唑、红霉素、利福平,氯霉素和甲硝唑影响OCS的报道。利福平与OCS的相互作用机理,是利福平诱导肝内微粒体酶而促进OCS代谢。其它
Oral steroid contraceptives (OCS) is still the most commonly used and reliable method of contraception. Although people have a broad understanding of the side effects of OCS, there is a lack of focus on the interaction of these and other drugs. As early as 1971 there was a report of contraceptive failure with the use of antibiotics while taking OCS, followed by reports of penicillin, ampicillin, amoxicillin, cephalexin, tetracycline, sulfamethazine, erythromycin, Fuping, chloramphenicol and metronidazole affect the OCS report. The mechanism of interaction between rifampicin and OCS is that rifampicin induces liver microsomal enzymes and promotes OCS metabolism. other