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目的:探讨水杨酸联合中药外敷对银屑病患者血清IL-2、IL-8、NO及肿瘤坏死因子的影响。方法:收集本院收治的寻常型银屑病患者60例,随机分为对照组和实验组,每组各30例,对照组给予水杨酸软膏治疗,实验组给予水杨酸软膏联合中药外敷治疗,治疗4周后,对所有患者的血清IL-2、IL-8、NO、TNF-α含量及临床疗效情况进行检测。结果:1实验组患者的血清IL-2水平较高,血清IL-8水平较低,差异具有统计学意义(P<0.05);2实验组患者的血清TNF-α水平较低(P<0.05);3实验组患者的NO、NOS水平较低(P<0.05);4实验组患者的实验组患者的总有效率较高(P<0.05)。结论:水杨酸联合中药外敷能够显著降低银屑病患者血清IL-8、NO、NOS及TNF-α含量,提高血清IL-2水平,提高临床疗效,对临床有指导意义。
Objective: To investigate the effects of salicylic acid combined with traditional Chinese medicine on serum IL-2, IL-8, NO and tumor necrosis factor in patients with psoriasis. Methods: Sixty patients with psoriasis vulgaris who were admitted to our hospital were randomly divided into control group and experimental group, with 30 cases in each group. Salicylic acid ointment was given to the control group. Salicylic acid ointment was given to the experimental group in combination with external application of traditional Chinese medicine After 4 weeks of treatment, the levels of IL-2, IL-8, NO, TNF-α in serum and clinical efficacy of all patients were detected. Results: 1 The levels of serum IL-2 and IL-8 in the experimental group were significantly lower than those in the experimental group (P <0.05); 2 The levels of serum TNF-α in the experimental group were lower (P <0.05 ). 3 The levels of NO and NOS in experimental group were lower (P <0.05). The experimental group had higher total effective rate (P <0.05). Conclusion: Salicylic acid combined with Chinese herbal medicine can significantly reduce the serum levels of IL-8, NO, NOS and TNF-α, increase the level of serum IL-2 and improve clinical efficacy in patients with psoriasis, which is of clinical significance.