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介绍应用双异丙吡胺治疗5例房颤的经验,其中4例成功,1例突发室颤死亡。认为本制剂能否使房颤复律取决于房颤病程的久暂、开始剂量是否足够,而与用药的累计剂量似无关系,推荐每日0.8克为治疗房颤的理想剂量。指出本制剂具有与奎尼丁相同的毒性作用。为防止突发室颤致死,建议在使用双异丙吡胺期间应密切进行临床和心电图监护并强调不宜于夜间给药。
Introduce the experience of using diflupiride in treating 5 cases of atrial fibrillation, of which 4 cases were successful and 1 case died of sudden ventricular fibrillation. That this preparation can make atrial fibrillation depends on the duration of atrial fibrillation for a long time to start the dose is sufficient, but with the cumulative dose of medication seems unrelated, the recommended daily 0.8 grams of the ideal dose for the treatment of atrial fibrillation. It is indicated that this preparation has the same toxic effect as quinidine. To prevent sudden death from ventricular fibrillation, it is recommended that both clinical and electrocardiographic monitoring should be performed closely during dialysis and that it is not appropriate to administer nighttime doses.