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目的研讨两种以上西药与头孢菌素类药物合用后所致药物不良反应(ADR)的种类及原因,以提高临床用药水平。方法从我院2014年10月-2016年8月随机选取1800张西药处方进行研究试验,按照我国卫生部、国家医药管理局相关规定,搜集与整理两种以上西药与头孢菌素类药物合用后发生ADR的处方,并做进一步分析。结果 1800张西药处方中,有725张为两种以上西药与头孢菌素类药物合用处方,所占比重为40.28%(725/1800)。其中有72张(9.93%)处方出现药物ADR,主要是神经系统症状(22.22%)、消化系统症状(19.44%)、肾功能损伤(18.06%)、过敏反应(16.67%)及二重感染(16.67%)等。结论临床在联合使用两种以上西药与头孢菌素类药物时,需明确掌握药物的性质、药学原理等,并加强相关药物ADR监测,以做到安全用药,高效治疗。
Objective To study the types and causes of adverse drug reaction (ADR) caused by combining two or more western medicines with cephalosporins in order to improve the clinical medication level. Methods A total of 1,800 prescriptions of western medicine were randomly selected from our hospital from October 2014 to August 2016. According to the relevant regulations of Ministry of Health and State Administration of Medicine, two kinds of western medicine and cephalosporins were collected and sorted out The ADR prescription occurred and was further analyzed. Results Among the 1800 western medicine prescriptions, 725 were prescriptions of two or more western medicines combined with cephalosporins, accounting for 40.28% (725/1800). Among them, 72 (9.93%) prescriptions appeared ADR, which were mainly nervous system symptoms (22.22%), digestive system symptoms (19.44%), renal dysfunction (18.06%), anaphylaxis (16.67%) and double infection 16.67%) and so on. Conclusion In the clinical use of more than two kinds of western medicine and cephalosporins drugs, the need to clearly grasp the nature of the drug, pharmacological principles, and strengthen the relevant drug ADR monitoring in order to achieve safe medication and efficient treatment.