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采用功能分析法在豚鼠离体右心房,观察心肌内源性组胺对不应期电场刺激诱发心肌正性变力效应的影响, 组氨酸1μmol/L孵育右心房标本以增加心肌组胺的合成,1h后施以电场刺激,心房肌正性变力效应较正常降低23.3%,雷尼替丁(1μmol/L)和扑尔敏(1μmol/L)对上述效应无影响。H_3受体拮抗剂burimamide可浓度依
Using functional analysis in isolated right atrium of guinea pigs, we observed the effects of endogenous histamine on cardiac positive degeneration induced by electric field stimulation in response to non-stimulated electric stimulation. Histidine at 1μmol / L incubated right atrium to increase myocardial histamine After 1 h, electric field stimulation resulted in a 23.3% decrease in a positive positive effect on atrial myocardium. Ranitidine (1 μmol / L) and chlorpheniramine (1 μmol / L) had no effect on these effects. H_3 receptor antagonist burimamide concentration dependent