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已知T淋巴细胞与细胞免疫功能、B淋巴细胞亚群与体液免疫功能有关。为了探讨淋巴细胞对癌细胞的反应即肿瘤局部的免疫状态,作者对45例未经治疗的头颈部鳞癌(鼻及鼻窦16,口腔6,咽10,喉13)的肿瘤标本,以抗人胸腺细胞血清(ATS)测定肿瘤组织内T、B细胞的分布,同时检查末梢血淋巴细胞数、淋巴细胞转化率及迟发型皮肤反应,分析癌组织的淋巴细胞浸润与免疫功能的关系。结果:(1)淋巴细胞多分布于癌细胞灶间的间质部分,少量分布于癌细胞灶内。其中80%为T细胞,B细胞则很少。(2)临床Ⅰ、Ⅱ期癌组织内T细胞浸润显著增多,Ⅲ、Ⅳ期的T细胞浸润减少。(3)在有所属淋
Known T lymphocytes and cellular immune function, B lymphocyte subsets and humoral immune function. In order to investigate the response of lymphocytes to cancer cells, ie, the local immune status of tumor, the authors of 45 cases of untreated head and neck squamous cell carcinoma (nasal and paranasal sinuses 16, oral cavity 6, pharynx 10, throat 13) The distribution of T and B cells in the tumor tissue was determined by human thymocyte serum (ATS). Meanwhile, the number of peripheral blood lymphocytes, the rate of lymphocyte transformation and the delayed skin reaction were examined. The relationship between lymphocyte infiltration and immune function was analyzed. Results: (1) Lymphocytes were mainly distributed in the interstitial part of cancer cells and a small amount distributed in cancer cells. Of which 80% of T cells, B cells are few. (2) The T cell infiltration in clinical stage Ⅰ and stage Ⅱ cancers increased significantly, and the infiltration of T cells in stages Ⅲ and Ⅳ decreased. (3) There is a shower