p S2属于三叶草因子家族 ,正常表达于胃组织 ,异位表达于胃肠道炎症和大量癌组织中。其表达受多种因素调节。p S2的功能可能与细胞运动、粘液聚合反应、细胞增殖 /分化有关。p S2也可能是一种神经肽。在胃肠道中 ,参与肿瘤的发生和维持粘膜的完整性 ;在乳腺癌中 ,可用来指导患者的预见性内分泌治疗 p S2 belongs to the clover factor family and is normally expressed in gastric tissue and ectopically expressed in gastrointestinal inflammation and in a large number of cancerous tissues. Its expression is regulated by many factors. The function of p S2 may be related to cell motility, muco-polymerization, cell proliferation / differentiation. p S2 may also be a neuropeptide. In the gastrointestinal tract, involved in tumorigenesis and maintain mucosal integrity; in breast cancer, can be used to guide the patient’s predictive endocrine therapy