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目的:探讨单硝酸异山梨酯联合多巴胺、呋塞米治疗顽固性心力衰竭的疗效及安全性。方法:对住院治疗的130例顽固性心力衰竭患者进行回顾性分析:在内科综合治疗的基础上将单硝酸异山梨酯25 mg、多巴胺20～40 mg、呋塞米40～80 mg加入5%葡萄糖注射液或0.9%氯化钠注射液50 ml,用微量泵6 ml/h速度开始静脉推注,1次/d,直至心力衰竭症状缓解,心功能改善后停止。结果:经治疗所有患者临床症状缓解、体征消失、心功能治疗前Ⅳ级,治疗后改善为Ⅰ～Ⅱ级。结论:内科综合治疗的基础上将单硝酸异山梨酯、多巴胺、呋塞米治疗顽固性心力衰竭是有效、安全、经济的治疗方案。
Objective: To investigate the efficacy and safety of isosorbide mononitrate combined with dopamine and furosemide in patients with refractory heart failure. Methods: A retrospective analysis of 130 patients with refractory heart failure admitted to hospital was conducted. Based on the comprehensive medical treatment, 25 mg of isosorbide mononitrate, 20-40 mg of dopamine and 40-80 mg of furosemide were added into 5% Glucose injection or 0.9% sodium chloride injection 50 ml, with a small pump 6 ml / h speed start intravenous bolus, 1 time / d, until the symptoms of heart failure to alleviate, improve cardiac function and stop. Results: The clinical symptoms of all patients were relieved, their signs disappeared, grade Ⅳ before cardiac function treatment, grade Ⅰ ~ Ⅱ after treatment. Conclusion: The treatment of intractable heart failure with isosorbide mononitrate, dopamine and furosemide is an effective, safe and economical treatment based on the comprehensive medical treatment.