Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,i.e.mechanotransduction~([1-3]).Focal adhesions are the major sites of interaction between a cell and its extracellular matrix(ECM)microenvironment,thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor integrins.In particular,it has been shown that matrix elasticity can control the cell fate~([4])by modulating the interactions between ECM proteins and their receptor integrins~([5,6]).For example,different rigidity of polyacrylamide(PA)gels can lead to different density of ECM ancho- Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells, iemechanotransduction ~ ([1-3]). Focal adhesions are the major sites of interaction between a cell and its extracellular matrix (ECM) microenvironment , thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor integrins. In particular, it has been shown that matrix elasticity can control the cell fate ~ ([4]) by modulating the interactions between ECM proteins and their receptor integrins ~ ( [5,6]). For example, different rigidity of polyacrylamide (PA) gels can lead to different density of ECM ancho-