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目的探讨PTEN与C-met在子宫内膜癌中的表达、意义及两者的关系。方法免疫组化SP法检测50例正常子宫内膜、55例子宫内膜癌标本中PTEN和C-met的表达。结果子宫内膜癌PTEN阳性率表达低于正常子宫内膜,差异有统计学意义(P<0.01),子宫内膜癌FIGO分期及组织分级间PTEN表达阳性率差异无统计学意义(P>0.05);子宫内膜癌C-met表达阳性率高于正常子宫内膜,差异有统计学意义(P<0.01),C-met表达阳性率随子宫内膜癌FIGO分期及组织分级的增高而增加,差异有统计学意义(P<0.05);子宫内膜癌中,PTEN与C-met呈负相关(P<0.05)。结论 PTEN和C-met可作为早期诊断子宫内膜癌的参考指标,C-met可作为判断子宫内膜癌预后的参考指标。
Objective To investigate the expression and significance of PTEN and C-met in endometrial carcinoma and their relationship. Methods Immunohistochemical SP method was used to detect the expression of PTEN and C-met in 50 cases of normal endometrium and 55 cases of endometrial carcinoma. Results The positive rate of PTEN in endometrial carcinoma was lower than that in normal endometrium (P <0.01), while the positive rate of PTEN in FIGO staging and histological grading of endometrial carcinoma had no statistical significance (P> 0.05 ). The positive rate of C-met expression in endometrial carcinoma was higher than that in normal endometrium (P <0.01). The positive rate of C-met expression was increased with the increase of FIGO stage and histological grade of endometrial carcinoma (P <0.05). In endometrial carcinoma, there was a negative correlation between PTEN and C-met (P <0.05). Conclusions PTEN and C-met can be used as early reference markers for the diagnosis of endometrial cancer. C-met can be used as a reference index for prognosis of endometrial cancer.