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本世纪五十年代以来,由于电生理及生物化学的进展,对 Ca~(2+)在机体中所起的作用有了更多的了解,特别是它在肌肉细胞浆中所出现的浓度,对肌肉的收缩活动起着关键性作用。1963年有人开始提出了 Ca 拮抗剂(Ca-antagonists)[1,2]的名称,并认为这类药物能选择性地阻断肌肉细胞膜外的 Ca~(2+)向膜内转运,减弱某些肌肉的收缩活动;后来开始应用于防治心绞痛和某些心率失常等,得到较好的疗效,从此出现了一类新药——Ca 拮抗剂,逐渐受到了,人们的注意。
Since the 1950s, due to the progress of electrophysiology and biochemistry, the role of Ca ~ (2+) in the body has been better understood, especially its concentration in the muscle cytoplasm, Shrink muscle activity plays a key role. In 1963, some people started to propose the names of Ca-antagonists [1, 2], and considered that these drugs could selectively block the transport of Ca 2+ into the membrane outside the muscle cell membrane, Some muscle contractile activity; later began to be used in the prevention and treatment of angina pectoris and some arrhythmia, get better curative effect, from there a new class of drugs - Ca antagonist, has been gradually, people’s attention.