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目的:分析简明国际神经精神访谈（轻）躁狂发作伴混合特征问卷［Mini International Neuropsychiatric Interview （Hypo-） Manic Episode with Mixed Features- DSM-5 Module，MINI-M］中文版在轻躁狂或躁狂发作患者中的信效度。方法:对MINI-M问卷汉化后，采用多中心、方便抽样的方法，抽取躁狂或轻躁狂发作患者（n n=110）进行问卷自评。以Cronbach′s α系数、条目与总分之间相关系数及重测相关系数评价MINI-M问卷的信度， 采用主成分分析及探索性因子分析结构效度，基于临床诊断的受试者操作特征曲线（receiver operating characteristic curve， ROC曲线）分析评价问卷的预测效度。n 结果:MINI-M问卷中文版Cronbach′s α为0.840，各条目与总分之间相关系数为0.549~0.834（n P<0.05），第1周末重测相关系数为0.621（n P<0.05）。主成分分析及探索性因子分析提取1个因子（对方差贡献率为55.795%）。ROC曲线分析显示，MINI-M≥2分为最佳临界值，其灵敏度、特异度分别为0.800和0.711，相应的混合特征检出率为38.2%（42/110），明显高于临床诊断率（18.2%，20/110）。n 结论:MINI-M问卷中文版在双相障碍躁狂或轻躁狂发作患者中具有良好的信效度，有助于提高临床医生对混合特征的识别与诊断率。“,”Objective:The reliability and validity of the Chinese version of Mini International Neuropsychiatric Interview (Hypo-) Manic Episode with Mixed Features- DSM-5 module (MINI-M) were tested in patients with a hypomanic or manic episode.Methods:After sinicization of MINI-M, a total of 110 patients with hypomanic or manic episode were recruited into this multiple-centre study through a convenience sampling, and completed the questionnaires by themselves. The reliability of MINI-M was analyzed with Cronbach′s α and Spearman′s r of item-to-total and test-retest correlations. Principal component analysis (PCA) and exploratory factor analysis (EFA) were conducted to explore the structural validity of MINI-M. questionnaire. The receiver operating characteristic curve (ROC) based on clinical diagnosis was used to analyze the predictive validity.Results:The internal consistency Cronbach′s α of the MINI-M was 0.840, the correlation coefficients of item-to-total were 0.549-0.834 (n P<0.05), the test-retest reliability over one-week interval was 0.621 (n P<0.05). The PCA and EFA supported a single factor with strong loadings for all 6 items, which could explain 55.795% of the total variance. The ROC analysis showed that the optimal cut-off was 2 for distinguishing mixed features from the manic episode with a sensitivity of 0.800 and a specificity of 0.711. The MINI-M determined 38.2%(42/110) of patients with mixed features, which was higher than 18.2% (20/110) diagnosed by routine psychiatric interview.n Conclusions:The findings demonstrate that the Chinese version of MINI-M is a reliable and valid tool for recognizing mixed features in patients with a hypomanic or manic episode, and helpful for raising the clinical diagnosis of mixed features.