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目的:分析第2代抗组胺药引起变态反应的特点,为不良反应的防治提供参考依据。方法:检索1986-2007年国内文献源第2代抗组胺药引起变态反应的资料。不良反应按WHO国际药品监测合作中心的方法分类。结果:54例变态反应报告中女性多于男性;引起不良反应的主要药物是阿司咪唑(29例)和西替利嗪(12例);不良反应预后较好。结论:患者的性别、合并用药等因素能影响不良反应的发生,对过敏性休克应特别警惕,减少不良反应的发生。
Objective: To analyze the characteristics of the second generation antihistamines causing allergic reactions and provide reference for the prevention and treatment of adverse reactions. Methods: The data of the second generation antihistamines causing allergic reaction in Chinese literatures from 1986 to 2007 were retrieved. Adverse reactions according to the WHO International Cooperative Medical Monitoring Center methods. Results: There were more women than men in the 54 allergy reports. Asimizoles (29 cases) and cetirizine (12 cases) were the main adverse reactions. The adverse reactions were better. Conclusion: The gender of patients, combined medication and other factors can affect the occurrence of adverse reactions, should be especially vigilant for anaphylactic shock and reduce the incidence of adverse reactions.