肿瘤进展的过程,即肿瘤细胞向周围组织侵袭的过程,常表现出细胞膜突起、细胞间粘着、连接丧失等特点。Ozcan等[1]认为是几种actin交联蛋白引起细胞骨架微丝重排的结果,Fascin是其中一种55 kD的肌动蛋白交联蛋白,在细胞运动中具有重要作用。Fascin的表达已被证明有一些上皮性肿瘤的疾病进展中有潜在作用,但目前较少研究探讨其在间质肿瘤的表达及临床相关性,Puppa等[2]研究了胃肠道间质瘤 The process of tumor progression, that is, the invasion of tumor cells to the surrounding tissue process, often showing the cell membrane protrusions, intercellular adhesion, the connection loss and so on. Ozcan et al. [1] considered the actin cross-linked proteins to act as cytoskeletal microfilament rearrangements. Fascin is one of the 55 kD actin cross-linked proteins and plays an important role in cell motility. Fascin expression has been shown to have potential role in the progression of some epithelial tumors, but few studies have investigated its expression in interstitial tumors and clinical relevance, Puppa et al [2] studied the gastrointestinal stromal tumors