目的研究Ⅱ型囊泡谷氨酸转运蛋白(vesicular glutamate transporter type 2,VGLUT2)在SD大鼠胰腺组织中的表达。方法采用双重荧光免疫组织化学的方法,观察VGLUT2在大鼠胰腺组织中的分布。结果 VGLUT2免疫反应阳性细胞分布在SD大鼠胰腺内分泌腺A细胞、B细胞和部分PP细胞,阳性物质分布于细胞质,D细胞及部分PP细胞无VGLUT2免疫活性。结论 VGLUT2在大鼠胰腺的表达提示VGLUT2可能在胰腺起着非常重要的作用。 Objective To study the expression of vesicular glutamate transporter type 2 (VGLUT2) in the pancreatic tissues of SD rats. Methods Double fluorescent immunohistochemistry was used to observe the distribution of VGLUT2 in rat pancreatic tissue. Results VGLUT2 immunoreactive cells were distributed in the endocrine A cells, B cells and some PP cells of SD rats. The positive substances were distributed in the cytoplasm. The D cells and some of the PP cells had no VGLUT2 immunoreactivity. Conclusion The expression of VGLUT2 in rat pancreas suggests that VGLUT2 may play a very important role in the pancreas.