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目的探讨经胰岛素强化治疗2型糖尿病患者并发低血糖的影响因素。方法选取2013年2月—2016年2月于梧州市红十字会医院实施胰岛素强化治疗的2型糖尿病患者740例,根据是否并发低血糖分为试验组(低血糖组)65例与对照组(非低血糖组)675例。比较两组患者年龄、性别、患病时间、并发症、是否联合用药,并分析患者并发低血糖的影响因素。结果患者低血糖发生率为8.78%(65/740)。两组患者性别、年龄比较,差异无统计学意义(P>0.05);试验组患者患病时间长于对照组,并发症、联合用药情况差于对照组(P<0.05)。多因素logistic回归分析结果显示,患病时间、并发症及联合用药是经胰岛素强化治疗2型糖尿病患者并发低血糖的危险因素。试验组患者低血糖发生时间以餐前为主,凌晨3点发生率最高。结论患病时间、并发症及联合用药是经胰岛素强化治疗2型糖尿病患者并发低血糖的危险因素。
Objective To investigate the influencing factors of hypoglycemia in type 2 diabetic patients treated with insulin. Methods From February 2013 to February 2016, 740 patients with type 2 diabetes underwent intensive insulin therapy at Wuzhou Red Cross Hospital were enrolled. According to whether hypoglycemia was involved in the test group (hypoglycemia group), 65 cases were compared with the control group Non-hypoglycemic group) 675 cases. The age, gender, duration of illness, complications and whether the combination therapy were compared between the two groups and the influencing factors of hypoglycemia were analyzed. Results The incidence of hypoglycemia in patients was 8.78% (65/740). There was no significant difference in gender and age between the two groups (P> 0.05). The prevalence of illness in the experimental group was longer than that in the control group, and complication and combination were worse than those in the control group (P <0.05). Multivariate logistic regression analysis showed that prevalence, complications and combination therapy were risk factors for hypoglycemia in patients with type 2 diabetes treated with insulin. The test group patients with hypoglycemia occurred mainly in the pre-meal, the highest incidence of 3:00. Conclusion The time of illness, complications and combination therapy are the risk factors of hypoglycemia in patients with type 2 diabetes treated with insulin.