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目的：比较欧必亭（Ｔｒｏｐｉｓｅｔｒｏｎ）和康泉（Ｋｙｔｒｉｌ）预防化疗所致恶心呕吐的疗效和不良反应。方法：采用随机自身对照方法，将３４例接受联合化疗（１９例含顺铂）的患者随机分为 Ａ、Ｂ两组，均接受２个周期相同方案的化疗。Ａ组第１周期用欧必亭，第２周期用康泉止吐；Ｂ组第１周期用康泉，第二周期用欧必亭止吐。结果：欧必亭和康泉第１天止吐的有效率分别为９４．１％和９７．１％，中位呕吐次数分别为４．５次和３次，经统计学处理两组差异无显著性。对迟发性呕吐和副作用也进行了对比，欧必亭和康泉也无明显差别。结论：欧必亭是一种预防化疗所致恶心呕吐的有效药物，它的不良反应很轻。
Objective: To compare the efficacy and adverse reactions of Tropisetron and Kytril in the prevention of nausea and vomiting caused by chemotherapy. METHODS: Thirty-four patients who received combination chemotherapy (19 patients with cisplatin) were randomly divided into two groups, A and B, and received two cycles of chemotherapy with the same protocol. The first cycle of group A was used with Obi-ting and the second cycle was with Kangquan antiemetic; group B was used with Kangquan in the first cycle, and the second cycle was treated with anti-tubing. Results: The effective rates of antiemetic on the first day of Obiting and Kangquan were 94.1% and 97.1%, and the median frequency of vomiting was 4.5 and 3 times respectively. There was no significant difference between the two groups after statistical treatment. . Delayed vomiting and side effects were also compared, and there was no significant difference between Obi-ting and Kangquan. Conclusion: Opitin is an effective drug to prevent nausea and vomiting caused by chemotherapy. Its adverse reactions are very light.