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Betatrophin是一种新发现的分泌性蛋白，是血管紧张素样蛋白家族中的新成员。在小鼠体内主要存在于肝脏及脂肪组织中，在人体内主要存在于肝脏中。在胰岛素抵抗小鼠中Betatrophin 有促进胰岛β细胞增殖、调节脂代谢以及改善糖耐量的作用。近几年对Betatrophin在人类2型糖尿病（T2DM）患者中的作用及其机制的研究取得了重大进展。 Betatrophin 在人类 T2DM 中水平相应增加，并与胰岛素抵抗、血糖水平及脂代谢密切相关，成为治疗糖尿病及改善糖尿病患者血脂紊乱药物新的作用靶点。“,”As a newly discovered secreted protein,Betatrophin is a new member of angiotensin like pro-tein family.It is expressed mainly in the liver and adipose tissue of mice and highly enriched in human liver . It could promote pancreatic βcell proliferation,regulate lipid metabolism and improve glucose tolerance in insulin resistant mice.Researches on the effect and mechanism of Betatrophin in human type 2 diabetes have made significant progress in recent years.Betatrophin is also elevated in patients with type 2 diabetes and cor-related with insulin resistance,serum glucose and lipid metabolism,which has become the new therapeutic target of diabetes and dyslipidemia.