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目的检测VEGF-D及D2-40在胃癌中的半定量表达,探讨二者在胃癌发生、发展及淋巴管生成中的作用。方法本实验以69例胃癌标本作为研究对象,16例正常胃黏膜作为对照,应用流式细胞术分析,分别检测VEGF-D和D2-40的表达,分析其在不同临床病理特征之间的关系。结果VEGF-D和D2-40在胃癌中的表达均明显高于正常胃黏膜组织;VEGF-D与D2-40的表达与胃癌的分化程度、浸润程度及有无淋巴结转移密切相关;VEGF-D与D2-40在胃癌中的表达呈正相关。结论VEGF-D及D2-40与胃癌的发生发展有密切关系,VEGF-D参与D2-40表达的淋巴管生成,二者表达可能与胃癌预后有一定关系。
Objective To detect the semi-quantitative expression of VEGF-D and D2-40 in gastric cancer, and to explore the role of VEGF-D and D2-40 in carcinogenesis, development and lymphangiogenesis of gastric cancer. Methods In this study, 69 cases of gastric cancer specimens as the research object, 16 cases of normal gastric mucosa as a control, the application of flow cytometry analysis, respectively, VEGF-D and D2-40 expression was analyzed and its relationship between different clinicopathological features . Results The expression of VEGF-D and D2-40 in gastric cancer was significantly higher than that in normal gastric mucosa. The expression of VEGF-D and D2-40 was closely related to the differentiation, infiltration and lymph node metastasis of gastric cancer. VEGF-D And D2-40 in gastric cancer was positively correlated. Conclusions VEGF-D and D2-40 are closely related to the occurrence and development of gastric cancer. VEGF-D is involved in lymphangiogenesis in D2-40 expression, which may be related to the prognosis of gastric cancer.