长期免疫记忆维持是否需要持续性抗原刺激一直是颇有争议的话题,探究该问题本质在于需要阐明记忆性免疫细胞究竟是对抗原产生真正记忆,或记忆性免疫细胞产生及维持只是机体对持续性抗原刺激免疫反应的结果.解决这一争论将给临床疫苗应用提供理论指导,为创新疫苗设计提供思路,也会启发我们开发新的针对自身免疫及肿瘤等人类重大疾病的免疫治疗. Whether long-term immune memory maintenance requires persistent antigen stimulation has been a controversial topic. The essence of exploring this issue is to elucidate whether memory immune cells actually produce antigenic memory or that memory immune cells produce and maintain only body-to-body continuity Antigens stimulate the immune response results.To resolve this controversy will provide theoretical guidance for clinical vaccine application, provide ideas for innovative vaccine design, will also inspire us to develop new immunotherapy for autoimmune and tumor and other major human diseases.