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目的 探讨在进展期胃癌根治术中一次性腹腔温热灌注化疗的治疗作用。方法 对术中行一次性腹腔温热灌注化疗的 30例进展期胃癌患者与未行此方法治疗的 15例患者的腹腔游离癌细胞检出率及预后等进行对比研究。结果 治疗组引流液中腹腔游离癌细胞检出率为 6 7% ,对照组为 33 3 % (P <0 .0 1)。治疗组 3 ,5年生存率分别为 6 0 %和46 7% ,对照组为 2 6 %和 13 3 % (P <0 .0 1)。结论 一次性腹腔温热灌注化疗具有杀灭腹腔游离癌细胞的作用 ,可改善进展期胃癌的预后
Objective To investigate the therapeutic effect of intraperitoneal hyperthermic perfusion chemotherapy in radical gastrectomy of advanced gastric cancer. Methods To compare the detection rate and prognosis of peritoneal free carcinoma in 30 patients with advanced gastric cancer undergoing intraperitoneal hyperthermic perfusion chemotherapy with 15 patients without this method. Results The detection rate of peritoneal free cancer cells in the drainage group was 67% in the control group and 33.3% in the control group (P <0.01). The 3-year and 5-year survival rates were 60% and 467% in the treatment group and 26% and 13 3% in the control group (P <0.01). Conclusion One-time intraperitoneal hyperthermic perfusion chemotherapy has the effect of killing peritoneal free cancer cells and can improve the prognosis of advanced gastric cancer