英夫利昔单抗治疗克罗恩病的有效性:一项随访15个月的多中心回顾性研究结果

来源 :世界核心医学期刊文摘(胃肠病学分册) | 被引量 : 0次 | 上传用户:liongliong488
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Objectives-To evaluate prescription practices and response to infliximab treatment for Crohn’s disease(CD).Patients and methods-The files of CD patients treated with at least one infusion of infliximab treated in gastroenterology units belonging to university teaching hospitals of the Parisian hospitals group(Assistance Publique-Hpitaux de Paris(AP-HP))during the year 2000 were analyzed retrospectively.Results-One hundred and thirty-seven patients(36.0 ±12.7 years,92 females)from 12 centers were studied.Indication for treatment was fistulae or perianal disease in 39%of patients,active Crohn’s disease in 45and mixed conditions in 16%.Mean follow-up was 15.2 ±7.2 months.The overall response rate was 85%.No predictive factor of sustained remission could be identified.The mean time to relapse was to 3.9 ±3.1 months.Thirty-eight patients were on maintenance therapy at the end of the follow-up;37%exhibiting progressive lost of response to treatment.Immunosuppressive therapy was added to infliximab in 78%of cases but response to infliximab was not modified by addition of immunosuppressive drugs.Adverse events,most frequently minor,were noted in 23%of the patients.Conclusion-This retrospective study confirms the efficacy and safety of infliximab in CD. Objectives-To evaluate prescription practices and response to infliximab treatment for Crohn’s disease (CD). Pats and methods-The files of CD patients treated with at least one infusion of infliximab treated in gastroenterology units belonging to university teaching hospitals of the Parisian hospitals group ( Assistance Publique-Hpitaux de Paris (AP-HP) during the year 2000 were analyzed retrospectively. Results-One hundred and thirty-seven patients (36.0 ± 12.7 years, 92 females) from 12 centers were studied. Indication for treatment was fistulae or perianal disease in 39% of patients, active Crohn’s disease in 45 and mixed conditions in 16% .Mean follow-up was 15.2 ± 7.2 months. The overall response rate was 85% .No predictive factor of sustained remission could be identified. mean time to relapse was 3.9 ± 3.1 months. Thirty-eight patients were on maintenance therapy at the end of the follow-up; 37% exhibiting progressive lost of response to treatment. Immunosuppressive therapy was added t o infliximab in 78% of cases but response to infliximab was not modified by addition of immunosuppressive drugs. Adverse events, most frequently minor, were noted in 23% of the patients. Conclusion - This retrospective study confirms the efficacy and safety of infliximab in CD .
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